Seattle Genetics (now Seagen Inc.) has a long and complex financial history marked by significant investments in research and development, strategic acquisitions, and a consistent focus on advancing its pipeline of antibody-drug conjugates (ADCs). For many years, the company operated at a loss, common for biotechnology companies focused on developing novel therapies. A substantial portion of their expenses was allocated to clinical trials, manufacturing development, and regulatory submissions related to their lead drug, Adcetris (brentuximab vedotin). Early funding rounds relied heavily on venture capital and private equity. As the company matured, it successfully navigated the public markets, raising capital through initial public offerings (IPO) and subsequent follow-on offerings. These offerings provided crucial funds to support ongoing research, expand clinical trial programs, and prepare for commercialization. The IPO, in particular, was a pivotal moment, signaling investor confidence in the company’s technology and future prospects. The approval and commercial launch of Adcetris in 2011 for the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma marked a significant turning point in the company’s financial trajectory. Adcetris sales provided a recurring revenue stream, allowing Seattle Genetics to reduce its reliance on external funding and invest more strategically in its pipeline. However, the company continued to invest heavily in R&D to explore Adcetris’ potential in other cancer types and to develop new ADC candidates. Strategic acquisitions have been a key component of Seattle Genetics’ financial strategy. These acquisitions have allowed the company to expand its technology platform, acquire promising ADC candidates, and strengthen its intellectual property portfolio. Such deals, while requiring substantial capital outlay, aimed to accelerate innovation and increase the company’s long-term value. Debt financing also played a role in the company’s capital structure. Seattle Genetics occasionally issued convertible notes or entered into loan agreements to access capital for specific purposes, such as financing acquisitions or expanding manufacturing capacity. Managing this debt effectively was crucial to maintaining financial flexibility and avoiding excessive interest expenses. Throughout its history, Seattle Genetics’ financial performance has been closely scrutinized by analysts and investors. Key metrics included revenue growth (driven primarily by Adcetris sales), R&D expenses, operating expenses, and cash flow. Maintaining a healthy cash runway was paramount, ensuring the company could fund its operations and pursue its strategic goals without facing immediate financial constraints. The company also focused on securing partnerships with other pharmaceutical companies to co-develop and commercialize its therapies, sharing the financial burden and potential risks associated with drug development. This strategy provided upfront payments, milestone payments, and royalties, bolstering the company’s financial position. In 2023, Pfizer acquired Seagen for $43 billion. This marked the culmination of years of strategic financial management and R&D investment, transforming Seagen from a promising biotech startup into a leading force in the oncology space. The acquisition demonstrates the significant value created by Seattle Genetics/Seagen over its history and underscores the importance of a well-executed financial strategy in the biopharmaceutical industry. The deal will significantly impact Pfizer’s financial performance and oncology pipeline, further solidifying their position in the cancer treatment market.